Chchd2 Uniprot
Immunocytochemistry Immunofluorescence - Anti-CHCHD2 antibody ab220688 Immunofluorescent analysis of PFA-fixed Triton X-100 permeabilized A431 cells labeling CHCHD2 with ab220688 at. Find Sigma-Aldrich-HPA027407 MSDS related peer-reviewed papers technical documents similar products more at Sigma-Aldrich.
Anti Chchd2 Antibody Ab220688 Abcam
Western blot analysis of subcellular fractions revealed that endogenous CHCHD2 is present in mitochondria appendix.
Chchd2 uniprot. In the first family the mutation segregated with disease but was. Adjusted HR 95 CI x axis of changes in UACR from baseline to 2-year visit for A all-cause mortality B cardiovascular death C composite cardiovascular outcome and D composite renal. CHCHD2 participant CRISPR screens 114 hits 1047 screens Download Results.
It has 2 annotated transcripts and 2 polypeptides all unique. UniProt is an ELIXIR core data resource. Phenotypes sequences polymorphisms proteins references function expression.
UniProt Consortium European Bioinformatics Institute Protein Information Resource SIB Swiss Institute of Bioinformatics. AL033347 Etohi6 coiled-coil-helix-coiled-coil-helix domain containing 2 Entrez Gene BioGRID MGI Alliance of Genome Resources VEGA Ensembl RefSeq GenBank Uniprot. The protein encoded by this gene belongs to a class of eukaryotic CX9C proteins characterized by four cysteine residue s spaced ten amino acids apart from one another.
As an important multifunctional protein involved in regulation of mitochondrial metabolism CHCHD2 was identified as a causative gene for Parkinsons disease PD yet the relationship between CHCHD2 and neurodegenerative dementia is not well understood. Advanced Filters A BioGRID. Here bioinformatic analyses revealed that CHCHD2 is consistently coamplified with EGFR in nonsmall cell lung carcinoma NSCLC.
It is a protein_coding_gene from Dmel. Anti-Coiled-coil-helix-Coiled-coil-helix domain containing 2Anti-C7orf17. Drosophila melanogaster Fruit fly Status.
UniProt is an ELIXIR core data resource. In addition CHCHD2 and EGFR protein expression levels were positively correlated and upregulated. The search result lists the genes found by the search function.
Anti-CHCHD2 antibody produced in rabbit Prestige Antibodies Powered by Atlas Antibodies affinity isolated antibody. CHCHD2 is a bi-organellar mediator of oxidative phosphorylation playing crucial roles in regulating electron flow in the mitochondrial electron transport chain and acting as a nuclear. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions 4 oxygen as well as normoxia conditions 20 oxygen PubMed23303788.
For more information and examples see the Search help. The gene Coiled-coil-helix-coiled-coil-helix domain containing 2 is referred to in FlyBase by the symbol DmelChchd2 CG5010 FBgn0260747. CHCHD2 C7orf17 protein expression summary.
CHCHD2 has a predicted N-terminal mitochondrial targeting sequence according to the UniProt database. The showhide columns function can be used to customize the columns in the search result list. CHCHD2 - The Human Protein Atlas.
Therefore we investigated whether CHCHD2 is located in mitochondria. UniProt for the human polypeptide sequence Q9NZQ7 which encodes a type I transmembrane protein of 290 amino acids consisting of a Ig V. View mouse Chchd2 Chr5129910002-129916311 with.
Anti-CHCHD2 antibody produced in rabbit Prestige Antibodies Powered by Atlas Antibodies affinity isolated antibody buffered aqueous glycerol solution. Therefore we investigated whether CHCHD2 is located in mitochondria. According to one embodiment the immunosuppressive polypeptide to be encoded by said exogenous coding sequence is an antagonist of PD1 such as PD-L1 other names.
CHCHD2 Q9Y6H1 15. It is an evolutionary conserved multifunctional protein localized primarily in the mitochondrial matrix and has roles in inflammation and infection processes mitochondrial ribosome biogenesis and regulation of apoptosis and nuclear. Coiled-coil-helix-coiled-coil-helix domain containing 2 d кешенең 7-нче хромосомасы d аксымы шул ук исемдәге ген тарафыннан кодлана.
We directly sequenced the entire coding region of CHCHD2 gene in 150 AD patients 84 FTD patients and 417 controls. These residues form disulfide linkages that define a CHCH fold. To refine the search results with specific criterias use the Fields.
Also known as p32 is a multi-compartmental protein whose precise function remains unknown. Anti-CHCHD2 antibody ab220688 at 1100 dilution. Western blot analysis of subcellular fractions revealed that endogenous CHCHD2 is present in mitochondria appendix.
2015 identified a C-to-T transition at nucleotide 182 of the CHCHD2 gene c182C-T NM_0161392 resulting in a threonine-to-isoleucine substitution at codon 61 T61I. Advanced Filters A BioGRID Project. UniProt Consortium European Bioinformatics Institute Protein Information Resource SIB Swiss Institute of Bioinformatics.
Protein-protein interaction databases. RT-4 cell line lysate. Find Sigma-Aldrich-HPA052510 MSDS related peer-reviewed papers technical documents similar products more at Sigma-Aldrich.
Chchd2 participant CRISPR screens 9 hits 51 screens Download Results. Complement component 1 Q subcomponent-binding protein C1QBP. 616710 Funayama et al.
CD274 Programmed cell death 1 ligand. CHCHD2 has a predicted N-terminal mitochondrial targeting sequence according to the UniProt database. In 2 unrelated Japanese families families A and C segregating autosomal dominant Parkinson disease 22 PARK22.
U-251 MG cell line lysate. UniProt Consortium European Bioinformatics Institute Protein Information Resource SIB Swiss Institute of Bioinformatics. Coiled-coil-helix-coiled-coil-helix domain-containing 2 a mitochondrial protein encoded by CHCHD2 is located at chromosome 7p112 and proximal to the EGFR gene.
Entrez Gene BioGRID MIM HGNC Alliance of Genome Resources VEGA Ensembl RefSeq GenBank Uniprot.
Academic Oup Com
Chchd2 Gene Genecards Chch2 Protein Chch2 Antibody
Chchd2 Gene Genecards Chch2 Protein Chch2 Antibody
Mitochondrial Proteins Containing Coiled Coil Helix Coiled Coil Helix Chch Domains In Health And Disease Trends In Biochemical Sciences
Chchd2 Polyclonal Antibody Anti Chchd2 St John S Labs
Chchd2 Gene Genecards Chch2 Protein Chch2 Antibody
Chchd2 Is Coamplified With Egfr In Nsclc And Regulates Mitochondrial Function And Cell Migration Molecular Cancer Research
Chchd2 Coiled Coil Helix Coiled Coil Helix Domain Containing 2 Gene Report Biogps
Anti Chchd2 Antibody Ab220688 Abcam
Chchd2 Is Coamplified With Egfr In Nsclc And Regulates Mitochondrial Function And Cell Migration Molecular Cancer Research
Anti Chchd2 Antibody Produced In Rabbit Prestige Antibodies Powered By Atlas Antibodies Affinity Isolated Antibody Buffered Aqueous Glycerol Solution
Chchd2 Gene Genecards Chch2 Protein Chch2 Antibody
Chchd2 Coiled Coil Helix Coiled Coil Helix Domain Containing 2
Chchd2 Is Coamplified With Egfr In Nsclc And Regulates Mitochondrial Function And Cell Migration Molecular Cancer Research
Chchd2 Is Coamplified With Egfr In Nsclc And Regulates Mitochondrial Function And Cell Migration Molecular Cancer Research
Chchd2 Chchd2 Xhpm
Supplemental Materials For Chchd2 Mutations In Autosomal Dominant Late Onset Parkinson S Disease A Genome Wide Linkage And Sequencing Study The Lancet Neurology
Chchd2 Is Coamplified With Egfr In Nsclc And Regulates Mitochondrial Function And Cell Migration Molecular Cancer Research
Chchd2 Polyclonal Antibody Anti Chchd2 St John S Labs